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Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. 4. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. >> 1 0 obj . AVICEL RC 581. It works as a moisture sponge and permits the controlled growth of spheroids. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Watch Now. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. >> BIOACCUMULATIVE POTENTIAL Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Avicel Microcrystalline Cellulose: Chemical Identifiers. Catalog Number 102331. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Quantity: 1 700 kgs. };khd5x=fr FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . 1 0 obj XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Battista, O. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. EINECS #: 232-674-9 1.7. Remove As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. An agricultural sciences company. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. We can send by Fedex, by ship or by plane according to international rules. Explore how we work and why we apply science and creativity for a better world to everything we do. Microcrystalline Cellulose (MCC) MSDS 1. <> In large quantities it provides dietary bulk and may lead to a laxative effect. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Heavy metals, % NMT 0.001 Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. (1962). Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, If breathing is difficult or if . stream LOT #: Available upon request. SDS - Safety Data Sheet. This Microcrystalline Cellulose . /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline Cellulose NF. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . %PDF-1.4 More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. << The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge It is hygroscopic and insoluble in water. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> CAS #: 9004-34-6 . P}MFbN#[>r(y Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . . % Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Product Name Cellulose microcrystalline. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. It is . if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. MATERIAL SAFETY DATA SHEET Version: 1.0 1. By producing Avicel . Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. ( AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Avicel PH-101. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. The data shown below apply only to Avicel PH 101. No. Go to Investor Relations. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. ( II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM PDF (28.38 mb) 2022 Corporate Fact Sheet. q9;v80q>jZ Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. undefined. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Date Approved: 05/25/2010. POLYOX resins are nonionic polyethylene oxide solubility polymers. Product Name: Microcrystalline Cellulose E460 1.2. Chemical Formula: (C6H10O5)n 1.4. 2 0 obj 6 0 obj Powder becomes slippery when wet. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. 1.3. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . endobj These, in turn, are assembled into fibrils in the cell wall. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. We are artists at heart and creators by nature. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Micro Crystalline Cellulose. endobj !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Terms and Conditions Compliance Solutions Industries About 3E News & Events . Biologicals by FMC. Some substance identifiers may have been claimed confidential, or may . To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. <> . : 51395-75-6 Date Approved: 01/31/2008 Revision No. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. <> It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Earth Supplied Products LLC. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Avicel Microcrystalline Cellulose Physical Properties. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Unique functionality for a broad range of pharmaceutical applications. : 160182 Date Approved: 05/25/2010 Revision No. (Microcrystalline Cellulose Market Pr. Request media, explore upcoming events and read our latest updates. B;vLZpHU%ChUyD+[ Combines good flow and high compactibility. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. In extrusion-spheronisation, it is the excipient of choice. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . << stream Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . %PDF-1.4 Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . It is, however, a good source of fibre. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Have an order or account question, find answers in our Online Support articles. Watch Now. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Test Data Available. Cellulose microcrystalline. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . All Rights Reserved. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Millipore. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. : 9004-34-6 Date Approved: 01/31/2008 . It is a white, free-flowing powder. 2008-2023 ChemPoint. Avicel PC 611 (FMC Biopolymer) Supplied by.